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Abdominal enlargement in dogs may occur due to a simple cause such as obesity, pregnancy, or intestinal parasites; however, it can also be a sign of different illnesses including hyperadrenocorticism, hypothyroidism, heart disease, organ enlargement trauma, GDV, and cancer. Identifying the cause of abdominal enlargement can take several steps starting with history and physical exam, progressing to screening tests including bloodwork and urinalysis. The CBC is assessed for signs of anemia, low platelets, or signs of inflammation. A biochemistry profile may reveal liver or kidney dysfunction, hypo- or hyperproteinemia, hypoglycemia, or other abnormalities. Urinalysis is used to fully interpret the biochemistry and check for abnormal urinary sediment. Based on the findings of the screening tests, additional diagnostics may include imaging, EKG, tissue biopsy, or fluid analysis.