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Dogs

  • Desoxycorticosterone pivalate (DOCP) (brand name Percorten-V®, Zycortal®) is a steroid hormone replacement therapy used to treat primary hypoadrenocorticism (Addison’s disease) in dogs. Extra-label (off-label) lower dosages of DOCP (i.e., lower dose, longer dosing interval, or both) can be used to control the balance of blood electrolyte levels. DOCP has also been used extra-label to treat hypoadrenocorticism in cats.

  • Robenacoxib (brand name: Onsior) is given by mouth in the form of a tablet to treat pain and inflammation associated with surgery or other musculoskeletal conditions in dogs and cats. Do not use this medication in pets that are allergic to it, or in pets concurrently using corticosteroids or other NSAIDs. If a negative reaction occurs, call your veterinary office.

  • Sulfadimethoxine is an antimicrobial given by mouth in the form of a tablet or liquid suspension, used primarily to treat coccidiosis. Its use for treating small mammals and reptiles is off label. Common side effects include vomiting, diarrhea, and decreased appetite. This medication should not be used in pets that are allergic to it, pregnant, lactating, or have severe liver or kidney dysfunction. If a negative reaction occurs, call your veterinary office.

  • Acetylsalicylic acid, or ASA (brand name Aspirin®), is used off label and is given by mouth in the form of a tablet to treat abnormal clotting. Do not use this medication in pets with bleeding disorders, in pets that are allergic to it, or in pets concurrently using corticosteroids or other NSAIDs.

  • Amoxicillin-clavulanic acid, also known as amoxicillin and clavulanate potassium (brand name Clavamox®), is a synthetic, penicillin-type antibiotic used to treat infections caused by gram-positive and gram-negative bacteria. It is used to treat skin infections, soft tissue infections, and periodontal disease. Amoxicillin-clavulanic acid comes in tablet and liquid suspension form.

  • Darbepoetin alfa is prescribed off label to treat low red blood cell levels (anemia) caused by progressing kidney disease in dogs and cats. It is administered by injections under the skin.

  • Docusate (Docusate Sodium Bloat Preparation, DSS, Dioctynate®, Pet-Enema®, Enema SA®, Docu-Soft®, Anti Gaz, Bloat Eze, Bloat Go, Bloat Release, Bloat Treatment, Bloat-Lax) is a laxative medication used to soften dry or hard stools and assist with constipation and bloating in animals. It is prescribed for use in dogs, cats, horses, cattle, goats, sheep, and rabbits, but is not recommended for reptiles due to potential fatalities.

  • Fluconazole is an antifungal medication used off label in cats, dogs, and small mammals to treat fungal infections, especially those in the brain and spinal cord. It is given by mouth in the form of a tablet or liquid suspension and is also available as an injection for hospital use. It should be used with caution in pets with liver or kidney disease, or pregnant or lactating pets.

  • Gemfibrozil is a medication prescribed off-label by veterinarians to treat high levels of fat (lipids) in the blood of dogs and cats when dietary modifications have not been effective. Occasionally, it is also used in birds for the same purpose. As a relatively new drug in veterinary medicine, its benefits, side effects, and adverse effects are still being determined.

  • Hyaluronan topical (Optixcare wipes®) are used to remove sticky mucus, eye secretions, and crusty debris from around the eyes of dogs, cats, and other small pets. They contain chamomile and hyaluron, which are gentle cleaning supplements. They are used to manage tear staining around the eyes in pets prone to this condition.