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  • Ronidazole is given by mouth and is used off label to treat Tritrichomonas foetus, trichomonas, and giardia in dogs, cats, and birds. It should not be used in farmed animals. Common side effects include vomiting and decreased appetite. Do not use in pets that are allergic to it or other nitroimidazoles such as metronidazole. If a negative reaction occurs, please call your veterinary office.

  • Selegiline is typically given by mouth and is used off and on label to treat signs due to cognitive dysfunction syndrome, pituitary dependent Cushing’s disease, anxiety and certain phobias. Side effects may include vomiting, diarrhea, drooling, lack of appetite, and behavioral changes. Do not use in pets that are allergic to it, are aggressive, or in pets receiving other MAOIs, including certain tick collars. If a negative reaction occurs, please call your veterinary office.

  • Sertraline is given by mouth and is used off label to treat behavior disorders in dogs and cats. Common side effects include tiredness, vomiting, diarrhea, lack of appetite, anxiety, irritability, sleeplessness, shaking, tremors, itchy skin, or panting. Do not use in pets that are allergic to it or other SSRIs, or pets that are using MAOIs, flea/tick collars, or cisapride. If a negative reaction occurs, please call your veterinary office.

  • Sotalol is given by mouth or injection and is used off label in dogs and cats to treat abnormal heart rhythms. The most common side effect is tiredness. Do not use in pets that are allergic to it or that have asthma, heart block, slow heart rate, uncontrolled congestive heart failure, or shock. If a negative reaction occurs, please call your veterinary office.

  • Spironolactone is given by mouth and is used off label to treat congestive heart failure, fluid accumulation, and other cardiovascular problems. Common side effects include increased drinking and urinating, mild decreases in energy, mild electrolyte imbalances, or vomiting/diarrhea. Do not use in pets that are allergic to it, have elevated potassium levels, Addison’s disease, acute kidney failure, significant kidney disease, that are not urinating or that may be used for breeding. If a negative reaction occurs, please call your veterinary office.

  • Tetracycline is given by mouth and is used off label to treat bacterial infections and inflammatory skin conditions in many animal species. The most common side effects include nausea, vomiting, diarrhea, and lack of appetite. Do not use in pets that are allergic to it or other tetracycline antibiotics, or in pregnant animals, especially in the first half of pregnancy. If a negative reaction occurs, please call your veterinary office.

  • Ursodiol is given by mouth and is used off label to treat gallbladder and biliary liver diseases. Give as directed by your veterinarian. Side effects are uncommon, but may include diarrhea and mild discomfort. Do not use in pets that are allergic to it or other bile acid products, or in rabbits, guinea pigs, or rodents. If a negative reaction occurs, please call your veterinary office.

  • Mexiletine is given by mouth and is used off label to treat abnormal heart rhythms and muscle disorders in dogs. Common side effects include stomach upset such as vomiting, trembling, or dizziness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

  • Amlodipine is given by mouth and is used on and off label to treat high blood pressure in cats and dogs. Common side effects include vomiting, diarrhea, lack of appetite, sleepiness, or gingival (gum) overgrowth. Do not use in pets that are allergic to it, are in shock, have aortic stenosis, or are in liver failure. If a negative reaction occurs, please call your veterinary office.

  • Azodyl® is a nutritional supplement that may decrease azotemia, a condition in which there is too much nitrogen (in the form of urea, creatinine, and other waste products) in the blood. Azotemia occurs in both dogs and cats that have chronic kidney disease (CKD). In theory, Azodyl® works by adding nitrogen-consuming bacteria into the intestines. Azodyl® should be considered an adjunct (secondary) treatment for CKD.